Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice
نویسندگان
چکیده
Bacterial leaf blight is one of the major diseases in rice and affects yields. Thus, various methods have been applied to protect rice from this disease. Here, we show systemic translocation of the human drug niclosamide (5-chloro-N-(2-chloro-4-nitrophenyl)2-hydroxybenzamide) in rice and its long-term effect on prevention of rice leaf blight. The development of Xanthomonas oryzae pv. oryzae-induced rice leaf blight was effectively inhibited in untreated systemic leaves as in niclosamide-treated leaves, although its effect gradually decreased in a time-dependent manner. Time-course examination after niclosamide treatment showed that the niclosamide level was highest after 3 h in non-treated distal leaves, suggesting fast systemic movement of niclosamide from the treated local site to untreated distal regions. Our data indicate that niclosamide controls rice leaf blight by its rapid systemic movement and that its effect is maintained for a long time.
منابع مشابه
Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice
Rice leaf blight, which is caused by the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo), results in huge losses in grain yield. Here, we show that Xoo-induced rice leaf blight is effectively controlled by niclosamide, an oral antihelminthic drug and molluscicide, which also functions as an anti-tumor agent. Niclosamide directly inhibited the growth of the three Xoo strains PXO99, 10208 ...
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Rice (Oryza sativa) is the leading source of nutrition for more than half of the world’s population, and by far it is the most important commercial food crop. But, its growth and production are significantly hampered by the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo) which causes leaf blight disease. Earlier studies have reported the antibacterial ability of FDA-approved niclosamide ...
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basis of their virulence against rice plants. Bui. Nat. Inst. Arg. Sci., C. 20, 67-82 (1966) 12) Mukoo, H., and Isaka, M.: Re-examination of some physiological characteristics of Xanthomonas oryzae (Uyeda et Ishiyama) Dowson. Ann.of Phytopath. Soc. Japan 29, 13-19 (1964) 13) Nishimura, Y., and Sakaguchi, S.: Heredity of resistance to bacterial leaf blight of rice. Preliminary report I. J. Genet...
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